Ilexhainanoside D( —— )

Catalog No. M31645 CAS No. 1137648-52-2

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Product Name

Ilexhainanoside D
Note

Research use only, not for human use.
Brief Description

Ilexhainanoside D is a natural product from Periploca sepiumBge.
Description

Ilexhainanoside D is a natural product from Periploca sepiumBge.
In Vitro

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In Vivo

The combination of Ilexhainanoside D and Ilexsaponin A (60, 120 or 240?mg/kg; for 8 weeks) treatment significantly reduces the severity of non-alcoholic fatty liver disease (NAFLD) induced by high-fat diet in a dose-dependent manner. The combination of Ilexhainanoside D and Ilexsaponin A treatment decreases the ratio of Firmicutes/Bacteroidetes, reduces the relative abundance of Desulfovibrio and increases the relative abundance of Akkermansia. The intestinal barrier is improved as evidenced by the upregulation of the expression of zonula occludens-1 (ZO-1) and occludin in the ileum. The combination of Ilexhainanoside D and Ilexsaponin A treatment reduces the entry of LPS into the circulation and decreases the hepatic gene expression levels of proinflammatory cytokines.
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