Taurocholic acid( —— )

Catalog No. M31531 CAS No. 81-24-3

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Product Name

Taurocholic acid
Note

Research use only, not for human use.
Brief Description

Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.
Description

Taurocholic acid is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathway.
In Vitro

Taurocholic acid (100 μM, 24 h) decreases the proportion of CD3+CD8+ T and NK cells in isolated PBMCs from HBeAg-positive CHB patients.Taurocholic acid (100 μM, 24 h) decreases IFN-α stimulated cytokine and cytotoxic granule levels (IFN-γ, TNF-α, granzyme B) in CD3+CD8+ T and NK cells.
In Vivo

Animal Model:C57BL/6 mice Dosage:100-mg/kg Administration:oral gavage, for 2 weeks after tail vein injection with rAAV8-1.3HBV for 6 weeks Result:Reduced the percentage of NK and CD3+CD8+ T cells.Increases serum HBsAg, HBeAg, and HBV DNA levels.
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