Spathulenol

Research use only, not for human use.

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway.

Spathulenol has immunomodulatory effect. Spathulenol shows the capacity to inhibit proliferation in the lymphocytes and to induce apoptosis in these cells possibly through a caspase-3 independent pathway; it presents moderate or low cytotoxicity with IC50 higher than 6uM, it is a good candidate to be used in combination chemotherapy of MDR cancer.

Spathulenolexhibits ahigh antioxidant activity s in the DPPH and MDA system,exhibits significant DPPH free radical activity, with IC50 values of85.60 μg/mL.

Spathulenol (oral administration; 300 mg/kg)shows a significant inhibition in the Cg-induced mice paw oedema and pleurisy model.In a spontaneous lipoperoxidation rat brain homogenate model, when incubated in controlled temperature and.oxygenation conditions, PG-1 exhibits a high activity with an IC50 value of 26.13 μg/mL, respectively, which is comparable to a commercial antioxidant BHT (38.41 μg/mL), Thus, PG-1 contributes to a decrease in the generation of MDA,which is a toxic product resulting from the degradation of the cell membrane by lipid peroxidation, causing cell ruptures and mutations.

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Others

Other Targets

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6750-60-3

220.4

C15H24O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (453.82 mM)

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(-20℃)

With Ice Pack

≥ 2 years