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CAY10602

CAS No. 374922-43-7

CAY10602( CAY10602 | CAY-10602 | CAY 10602 )

Catalog No. M18489 CAS No. 374922-43-7

CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 42 In Stock
5MG 29 In Stock
10MG 38 In Stock
25MG 83 In Stock
50MG 152 In Stock
100MG 259 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    CAY10602
  • Note
    Research use only, not for human use.
  • Brief Description
    CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate.
  • Description
    CAY10602 is a SIRT1 activator. CAY10602 was derived from high throughput screening for compounds that increase SIRT1-mediated deacetylation of a SIRT1-specific substrate. Functional assays show that CAY10602 dose-dependently suppresses the NF-κB-dependent induction of TNF-α by lipopolysaccharide in THP-1 cells, with approximately 75% inhibition achieved at 60 μM, without cytotoxicity.
  • In Vitro
    Compounds (including CAY10602/compound 1) with SIRT1-activating properties have a significant effect on fat mobilization in differentiated adipocytes, and these compounds (including CAY10602) have antiobesity and/or antidiabetic properties. Compounds (including CAY10602) with SIRT1 activating potential exert strong suppression of TNF-α release at concentrations between 20 and 60 μM.
  • In Vivo
    ——
  • Synonyms
    CAY10602 | CAY-10602 | CAY 10602
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SIRT1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    374922-43-7
  • Formula Weight
    418.44
  • Molecular Formula
    C22H15FN4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 100 mg/mL 238.98 mM
  • SMILES
    Fc1ccc(cc1)n1c2nc3ccccc3nc2c(c1N)S(=O)(=O)c1ccccc1
  • Chemical Name
    1-(4-fluorophenyl)-3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]quinoxalin-2-amine

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. H?ppner S, et al. Fragmentation studies of SIRT1-activating drugs and their detection in human plasma for doping control purposes. Rapid Commun Mass Spectrom. 2013 Jan 15;27(1):35-50.
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