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RFRP-1 (human)
CAS No. 311309-25-8
RFRP-1 (human)( —— )
Catalog No. M30817 CAS No. 311309-25-8
Potent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
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Biological Information
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Product NameRFRP-1 (human)
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NoteResearch use only, not for human use.
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Brief DescriptionPotent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.
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DescriptionPotent endogenous NPFF receptor agonist (EC50 values are 0.0011 and 29 nM for NPFF2 and NPFF1, respectively). Attenuates contractile function of isolated rat and rabbit cardiac myocytes. Reduces heart rate, stroke volume, ejection fraction and cardiac output, and increases plasma prolactin levels in rats. GnIH homolog.
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In Vitro——
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In VivoRFRP-1(human) rapidly and reversibly decreases shortening and relaxation in isolated mammalian cardiac myocytes in a dose dependent manner.Intravenous injection of RFRP-1(human) in mice decreases heart rate, stroke volume, ejection fraction, and cardiac output.
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Synonyms——
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PathwayGPCR/G Protein
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TargetNeuropeptide Y Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number311309-25-8
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Formula Weight1428.72
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Molecular FormulaC67H101N19O14S
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 100 mg/mL (69.99 mM)
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SMILES[H]N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gouardères et al (2006) Functional differences between NPFF1 and NPFF2 receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of [35S]GTPγS binding. Neuropharmacology 52 376 PMID:
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