Potent galanin receptor 2/3 (GAL2/GAL3) agonist (EC50 values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.

BIBO 3304 is a potent, selective, nonpeptide neuropeptide Y Y1 receptor antagonist with IC50 of 0.38 and 0.72 nM for human and the rat Y1 receptor, respectively.

AC-099 hydrochloride is a selective full agonist of the neuropeptide FF2 receptor NPFF2R (EC50=1189 nM) and partial agonist function of the neuropeptide FF1 receptor NPFF1R (EC50=2370 nM) that reverses opioid-induced nociceptive sensitization, and may be used to study neurological.