K-(D-1-Nal)-FwLL-NH2( —— )

Catalog No. M30655 CAS No. 1394288-22-2

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Product Name

K-(D-1-Nal)-FwLL-NH2
Note

Research use only, not for human use.
Brief Description

High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
Description

High affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.
In Vitro

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In Vivo

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Synonyms

——
Pathway

GPCR/G Protein
Target

GHSR
Recptor

——
Research Area

——
Indication

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CAS Number

1394288-22-2
Formula Weight

902.13
Molecular Formula

C51H67N9O6
Purity

>98% (HPLC)
Solubility

water:2 mg/mL
SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@H](CC1=CC=CC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
Chemical Name

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1. Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID:

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