Orphanin FQ (1-11)( —— )

Catalog No. M30609 CAS No. 178249-41-7

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Product Name

Orphanin FQ (1-11)
Note

Research use only, not for human use.
Brief Description

Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
Description

Peptide fragment containing amino acids 1-11 of Nociceptin. Potent agonist of the ORL1/KOR-3 receptor (Ki = 55 nM); displays no affinity for opioid receptors, including μ, δ, κ1 and κ3 receptors (Ki >1000 nM). Displays analgesic properties in CD-1 mice.
In Vitro

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In Vivo

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Synonyms

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Pathway

Endocrinology/Hormones
Target

Opioid Receptor
Recptor

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Research Area

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Indication

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CAS Number

178249-41-7
Formula Weight

1098.2
Molecular Formula

C49H75N15O14
Purity

>98% (HPLC)
Solubility

20% acetonitrile / water:2 mg/mL
SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)NCC(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(O)=O
Chemical Name

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1. Rossi et al (1997) Pharmacological characterization of orphanin FQ/nociceptin and its fragments. J.Pharmacol.Exp.Ther. 282 858 PMID:

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