Cart
sales@molnova.com
LY2444296
CAS No. 1346133-11-6
LY2444296( —— )
Catalog No. M33001 CAS No. 1346133-11-6
LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
|
| 10MG | 70 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameLY2444296
-
NoteResearch use only, not for human use.
-
Brief DescriptionLY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).
-
DescriptionLY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ～1 nM. LY2444296 exhibits anti-anxiety like effects.
-
In Vitro——
-
In VivoLY2444296 displays anti-anxiety like effects in the EPM test.LY2444296 (3 mg/kg; i.p.; 30 min before U69,593 administration) prevents behavioral and neuroendocrine effects caused by the reference kappa agonist U69,593 in cocaine-na?ve rats.LY2444296 reduces anxiety-like and depressive-like behaviors, as well as CORT release, in rats tested after chronic extended access cocaine self-administration, but not in cocaine-na?ve rats.Animal Model:Adult male Sprague Dawley rats (240–250 g)Dosage:3 mg/kg Administration:Injected intraperitoneally; 30 min before U69,593 administration Result:Prevented behavioral and neuroendocrine effects caused by U69,593 in cocaine-na?ve rats.
-
Synonyms——
-
PathwayEndocrinology/Hormones
-
TargetOpioid Receptor
-
RecptorOpioid Receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1346133-11-6
-
Formula Weight408.44
-
Molecular FormulaC24H22F2N2O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?Ethanol : 27.5 mg/mL (67.33 mM; Ultrasonic)
-
SMILESNC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccc(F)c3)cc2)c(F)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20.?
molnova catalog
related products
-
Spiradoline
Spiradoline (U 62066) is a potent, highly selective κ-opioid agonist that has analgesic diuretic and antitussive effects.
-
[Arg14,Lys15]Nocicep...
Highly potent and selective NOP receptor agonist (EC50 = 1 nM). Displays > 875-fold selectivity over opioid receptors (IC50 values are 0.32, 280, > 10000 and 1500 for NOP, μ, δ and κ receptors respectively). Longer lasting and 30-fold more potent than nociceptin in vivo; pronociceptive and inhibits locomotor activity.
-
Adrenorphin 3TFA(883...
Adrenorphin(3TFA) is an agonist of μ-opioid receptor(Ki :12 nM).
