PL 017( —— )

Catalog No. M30590 CAS No. 83397-56-2

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Product Name

PL 017
Note

Research use only, not for human use.
Brief Description

Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.
Description

Selective μ opioid receptor agonist (IC50 values are 5.5 and > 10000 nM for inhibition of 125I-FK 33,824 and 125I-DADLE binding to μ and δ sites respectively). Produces naloxone-reversible analgesia, catalepsy and hyperthermia following central administration in rats in vivo.
In Vitro

PL-017 has an IC50 of 10000 nM for 125I-DADLE binding to δ site.
In Vivo

PL-017 (0.22, 0.45, 0.9 nmol/rat; i.c.v.) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g.
Synonyms

——
Pathway

Endocrinology/Hormones
Target

Opioid Receptor
Recptor

——
Research Area

——
Indication

——

CAS Number

83397-56-2
Formula Weight

535.64
Molecular Formula

C29H37N5O5
Purity

>98% (HPLC)
Solubility

water:1 mg/mL
SMILES

[H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(N)=O
Chemical Name

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1. Chang et al (1983) Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J.Pharmacol.Exp.Ther. 227 403 PMID:

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