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Naltrexone hydrochloride
CAS No. 16676-29-2
Naltrexone hydrochloride( NIH 8503 )
Catalog No. M12543 CAS No. 16676-29-2
A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | 45 | In Stock |
|
| 200MG | 57 | In Stock |
|
| 500MG | 103 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameNaltrexone hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
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DescriptionA potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).Alcoholism Approved.
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In Vitro——
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In Vivo——
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SynonymsNIH 8503
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PathwayEndocrinology/Hormones
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TargetOpioid Receptor
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RecptorOpioidReceptor
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Research AreaNeurological Disease
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IndicationAlcoholism
Chemical Information
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CAS Number16676-29-2
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Formula Weight377.8618
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Molecular FormulaC20H24ClNO4
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 33 mg/mL
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SMILESC1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
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Chemical NameMorphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride (1:1), (5α)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70.
2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809.
3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
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