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Naltrexone hydrochloride

CAS No. 16676-29-2

Naltrexone hydrochloride( NIH 8503 )

Catalog No. M12543 CAS No. 16676-29-2

A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 37 In Stock
25MG 29 In Stock
50MG 34 In Stock
100MG 47 In Stock
200MG Get Quote In Stock
500MG 105 In Stock
1G 154 In Stock
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Biological Information

  • Product Name
    Naltrexone hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively.
  • Description
    A potent, competitive antagonist for μ, κ, δ, and σ-opioid receptors with Ki of 0.0825 nM, 0.509 nM, and 8.02 nM, for MOR, KOR, and DOR, respectively; also inhibits IL-6 and TNFα production in human immune cell subsets following stimulation with ligands for intracellular TLRs; a TLR-4 antognist that inhibits LPS-induced TLR4 downstream NO production in microglia BV-2 cells (IC50=105 uM).Alcoholism Approved.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    NIH 8503
  • Pathway
    Endocrinology/Hormones
  • Target
    Opioid Receptor
  • Recptor
    OpioidReceptor
  • Research Area
    Neurological Disease
  • Indication
    Alcoholism

Chemical Information

  • CAS Number
    16676-29-2
  • Formula Weight
    377.8618
  • Molecular Formula
    C20H24ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 33 mg/mL
  • SMILES
    C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
  • Chemical Name
    Morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxy-, hydrochloride (1:1), (5α)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Codd EE, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1263-70. 2. Cant R, et al. Front Immunol. 2017 Jul 11;8:809. 3. Selfridge BR, et al. J Med Chem. 2015 Jun 25;58(12):5038-52.
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