P11

Research use only, not for human use.

Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group.The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM.HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression. Cell Proliferation Assay Cell Line:HUVEC cells.Concentration:0.1, 1, 10, and 100 μg/mL.Incubation Time:72 h.Result:Significantly inhibited HUVEC proliferation on denatured collagen-coated plates in a dose-dependent manner.

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Cell Cycle/DNA Damage

Integrin

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848644-86-0

720.78

C30H48N12O9

>98% (HPLC)

water:2 mg/mL

[H]N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years