α2β1 integrin-IN-15( —— )

Catalog No. M16585 CAS No. 916734-43-5

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HNMR

HPLC

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Product Name

α2β1 integrin-IN-15
Note

Research use only, not for human use.
Brief Description

α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM.
Description

α2β1 integrin-IN-15 highly potent, selective, allosteric small-molecule inhibitor of integrin α2β1 with IC50 of 12 nM; ihibits adhesion of cells expressing wild-type (WT) and demonstrates no effect on RBL cells expressing an activating I-domain mutation (E318A), inhibits an activating cytoplasmic domain mutant [Del(GFFKR)] with an IC50 ≈4-fold higher than for wild-type integrin α2β1; shows efficacious activity in an animal model of arterial thrombosis.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Cell Cycle/DNA Damage
Target

Integrin
Recptor

Integrin
Research Area

——
Indication

——

CAS Number

916734-43-5
Formula Weight

520.619
Molecular Formula

C23H28N4O6S2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 250 mg/mL (480.20 mM)
SMILES

CC1(C(N(CS1)S(=O)(=O)C2=CC=CC=C2)C(=O)NC(CNC(=O)NCC3=CC=CC=C3)C(=O)O)C
Chemical Name

(S)-3-(3-benzylureido)-2-((R)-5,5-dimethyl-3-(phenylsulfonyl)thiazolidine-4-carboxamido)propanoic acid

1. Miller MW, et al. Proc Natl Acad Sci U S A. 2009 Jan 20;106(3):719-24.

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