Fz7-21( —— )

Catalog No. M29962 CAS No. 2247635-23-8

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Product Name

Fz7-21
Note

Research use only, not for human use.
Brief Description

Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).
Description

Fz7-21 is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)
Research Area

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Indication

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