β-Amyloid 1-15( Amyloid β-Protein (1-15) )

Catalog No. M29928 CAS No. 183745-81-5

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Datasheet

HNMR

HPLC

MSDS

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Product Name

β-Amyloid 1-15
Note

Research use only, not for human use.
Brief Description

This is a fragment of beta-amyloid peptide. It has amino acids 1 through 15.
Description

This is a fragment of beta-amyloid peptide. It has amino acids 1 through 15.(In Vitro):β-Amyloid (1-15) is produced by concerted β- and α-secretase cleavage of amyloid-β protein precursor (AβPP). β-Amyloid (1-15) seems to be a sensitive acute pharmacodynamic biomarker for γ-secretase inhibition and may have several advantages compared to measuring longer CSF Aβ species.
In Vitro

β-Amyloid (1-15) is produced by concerted β- and α-secretase cleavage of amyloid-β protein precursor (AβPP). β-Amyloid (1-15) seems to be a sensitive acute pharmacodynamic biomarker for γ-secretase inhibition and may have several advantages compared to measuring longer CSF Aβ species.
In Vivo

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Synonyms

Amyloid β-Protein (1-15)
Pathway

Membrane Transporter/Ion Channel
Target

Beta Amyloid
Recptor

Amyloid-β
Research Area

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Indication

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CAS Number

183745-81-5
Formula Weight

1826.84
Molecular Formula

C78H107N25O27
Purity

>98% (HPLC)
Solubility

In Vitro:?H2O : 50 mg/mL (27.37 mM)
SMILES

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Chemical Name

Sequence:Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln

Portelius E, et al. Amyloid-β(1-15/16) as a marker for γ-secretase inhibition in Alzheimer's disease. J Alzheimers Dis. 2012;31(2):335-41.

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