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Humantenmine
CAS No. 82354-38-9
Humantenmine( —— )
Catalog No. M19144 CAS No. 82354-38-9
Humantenmine and koumine may inhibit several CYP450 enzyme activities.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 132 | In Stock |
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| 5MG | 136 | In Stock |
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| 10MG | 217 | In Stock |
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| 25MG | 370 | In Stock |
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| 50MG | 538 | In Stock |
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| 100MG | 770 | In Stock |
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| 200MG | 1051 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameHumantenmine
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NoteResearch use only, not for human use.
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Brief DescriptionHumantenmine and koumine may inhibit several CYP450 enzyme activities.
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DescriptionHumantenmine is a toxic compound isolated from Gelsemium elegans Benth. Humantenmine and koumine may inhibit several CYP450 enzyme activities.
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In VitroHumantenmine (HMT) decreases the 14-day survival rate of the mice to 17% after they are intragastrically treated with HMT, along with hepatic injury and increasing alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels. CYP3A4/5 mediates the metabolism and detoxification of HMT.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetBeta Amyloid
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RecptorCYP450
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Research AreaOthers-Field
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Indication——
Chemical Information
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CAS Number82354-38-9
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Formula Weight326.39
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Molecular FormulaC19H22N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (306.38 mM)
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SMILESCCC1=NC2CC3(C4CC1C2CO4)C5=CC=CC=C5N(C3=O)OC
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Lecanemab
Lecanemab (BAN-2401) is an IgG1 monoclonal antibody targeting soluble aggregated β-amyloid (Abeta) with activity against oligomers, protofibrils, and insoluble protofibrils, and may be useful in the study of Alzheimer's disease (AD)-induced mild cognitive impairment and mild AD dementia.
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β-Amyloid 1-9
This is an N-terminal fragment of beta amyloid. It consists of amino acid residues 1 to 9. Truncated beta amyloid peptide (10-40) still forms amyloid fibrils and shows fibril polymorphism.
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RAGE antagonist pept...
Receptor for advanced glycation end products (RAGE) antagonist. Blocks S100P, S100A4 and HMGB-1 mediated RAGE activation in vitro and in vivo. Inhibits growth and metastasis of rat glioma tumors. Reduces cell growth and RAGE-mediated NF-κB activity in human PDAC cell lines. Inhibits effects of TDI exposure in BALB/c mice.
