Kukoamine A

Research use only, not for human use.

Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).

Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a mixed inhibitor (Ki = 1.8 microM).(In Vitro):The four possible regioisomers of Kukoamine A, as well as a series of Kukoamine A analogs incorporating changes in either the SPM or the DHCA structural units, were evaluated for their antioxidant activity and their inhibitory activity on soybean lipoxygenase (LOX) and lipid peroxidation. The reducing properties of the compounds were evaluated using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging assay and found to be in the range 5-97.5%. Kukoamine A significantly inhibits LOX with IC50 9.5 microM. All tested analogs inhibited lipid peroxidation in the range of 11-100%.(In Vivo):Kukoamine A has neuroprotective effects through inhibiting oxidative stress and apoptosis after whole-brain irradiation (WBI) in rats.

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Apoptosis

NF-κB

NF-κB

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75288-96-9

530.666

C28H42N4O6

>98% (HPLC)

In Vitro:?H2O : 125 mg/mL (235.56 mM)

Oc1ccc(CCC(=O)NCCCNCCCCNCCCNC(=O)CCc2ccc(O)c(O)c2)cc1O

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(-20℃)

With Ice Pack

≥ 2 years