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PARP1-IN-8?
CAS No. 836640-15-4
PARP1-IN-8?( N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide )
Catalog No. M28956 CAS No. 836640-15-4
PARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 141 | In Stock |
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| 10MG | 226 | In Stock |
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| 25MG | 378 | In Stock |
|
| 50MG | 527 | In Stock |
|
| 100MG | 714 | In Stock |
|
| 200MG | 918 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NamePARP1-IN-8?
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NoteResearch use only, not for human use.
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Brief DescriptionPARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).
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DescriptionPARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).(In Vitro):PARP1-IN-8 (0, 0.1, 1, 10 μM; 24, 48 h) showed significantly potent anti-proliferative activity against A549 cells and didn’t display any significant cytotoxicity on HFF cells.
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In VitroPARP1-IN-8 (compound 11c) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells. Cell Proliferation Assay Cell Line:A549, HFF cells Concentration:0, 0.1, 1, 10 μM Incubation Time:24, 48 h Result:Showed significantly potent anti-proliferative activity against A549 cells, and didn’t display any significant cytotoxicity on HFF cells.
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In Vivo——
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SynonymsN-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorBRD4
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Research Area——
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Indication——
Chemical Information
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CAS Number836640-15-4
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Formula Weight403.87
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Molecular FormulaC23H18ClN3O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (154.76 mM)
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SMILESClc1cccc(NC(=O)CCn2nc(-c3ccccc3)c3ccccc3c2=O)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957.
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