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PARP1-IN-8?

CAS No. 836640-15-4

PARP1-IN-8?( N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide )

Catalog No. M28956 CAS No. 836640-15-4

PARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PARP1-IN-8?
  • Note
    Research use only, not for human use.
  • Brief Description
    PARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).
  • Description
    PARP1-IN-8 is an effective inhibito of PARP1 (IC50 = 97 nM).(In Vitro):PARP1-IN-8 (0, 0.1, 1, 10 μM; 24, 48 h) showed significantly potent anti-proliferative activity against A549 cells and didn’t display any significant cytotoxicity on HFF cells.
  • In Vitro
    PARP1-IN-8 (compound 11c) (0-10 μM, 24-48 h) shows significantly potent anti-proliferative activity against A549 cells. Cell Proliferation Assay Cell Line:A549, HFF cells Concentration:0, 0.1, 1, 10 μM Incubation Time:24, 48 h Result:Showed significantly potent anti-proliferative activity against A549 cells, and didn’t display any significant cytotoxicity on HFF cells.
  • In Vivo
    ——
  • Synonyms
    N-(3-chlorophenyl)-3-(1-oxo-4-phenylphthalazin-2(1H)-yl)propanamide
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    BRD4
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    836640-15-4
  • Formula Weight
    403.87
  • Molecular Formula
    C23H18ClN3O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 62.5 mg/mL (154.76 mM)
  • SMILES
    Clc1cccc(NC(=O)CCn2nc(-c3ccccc3)c3ccccc3c2=O)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Jennings LE, et al. BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability. Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957.
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