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ZINC05007751
CAS No. 591239-68-8
ZINC05007751( —— )
Catalog No. M28948 CAS No. 591239-68-8
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 70 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 187 | In Stock |
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| 25MG | 353 | In Stock |
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| 50MG | 555 | In Stock |
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| 100MG | 792 | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameZINC05007751
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NoteResearch use only, not for human use.
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Brief DescriptionZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
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DescriptionZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.(In Vitro):In ovarian cancer cells PEO1, ZINC05007751 induced perturbation of the cell cycle. ZINC05007751 showed synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 μM, with a combination of ZINC05007751 (44 μM) + Cisplatin (10 μM) exhibiting the greatest synergistic effect. ZINC05007751 (6 μM-190 μM; 24 hours) inhibited the growth of MDA-MB-231, PEO1, NCI-H1299, and HCT-15 with IC50 below 100 μM.
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In VitroZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100?μM.ZINC05007751 induces perturbation of PEO1 cell cycle.ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1??μM, with combination ZINC05007751 (44?μM)?+?Cisplatin (10?μM) exhibiting the greatest synergistic effect. Cell Cytotoxicity Assay Cell Line:MDA-MB-231, PEO1, NCI-H1299 and HCT-15 cells Concentration:6 μM-190 μM Incubation Time:24?hours Result:Inhibited the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15.
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In Vivo——
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Synonyms——
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PathwayMAPK/ERK Signaling
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Targetp38 MAPK
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RecptorATX (autotaxin)
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Research Area——
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Indication——
Chemical Information
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CAS Number591239-68-8
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Formula Weight304.305
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Molecular FormulaC18H12N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 8.33 mg/mL (27.37 mM)
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SMILESCC1=C(C#N)C(O)=NC(=O)\C1=C/c1ccc(o1)-c1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.LEE, Dae Yon, et al. NOVEL COMPOUNDS AS AUTOTAXIN INHIBITORS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME. Patent O2018212534A1
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