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Home - Products - MAPK/ERK Signaling - p38 MAPK - SB 239063

SB 239063

CAS No. 193551-21-2

SB 239063( SB-239063 | SB239063 )

Catalog No. M13031 CAS No. 193551-21-2

A potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 67 In Stock
2MG 55 In Stock
5MG 85 In Stock
10MG 154 In Stock
25MG 335 In Stock
50MG 492 In Stock
100MG 713 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
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Biological Information

  • Product Name
    SB 239063
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β.
  • Description
    A potent, selective, orally available p38 MAPK inhibitor with IC50 of 44 nM for both p38α and p38β; shows no activity (>100 μM) against the γ- and δ-kinase isoforms, and a panel of protein kinase; inhibits IL-1 and TNF-alpha production in LPS-stimulated human PBMCs (IC50= 0.12 and 0.35 uM); reduces inflammatory cytokine production, airways eosinophil infiltration and persistence in vivo.
  • In Vitro
    Apoptosis Analysis Cell Line:Eosinophils (guinea pig BALs) Concentration:0.1μM, 1μM, 10μM Incubation Time:29 hours, 47 hours Result:Increased apoptosis of eosinophils in a dose-related in the presence of 10 pM IL-5 at every time point from 21 hours onwards.
  • In Vivo
    Animal Model:Male BALB/c mice (18–20 g) Dosage:12 mg/kg Administration:Oral administration; 1 h before and 4 h after OA challenge; bis in die for 3 days Result:Significantly inhibited the resultant antigen-induced airway eosinophilia.
  • Synonyms
    SB-239063 | SB239063
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    p38α|p38β
  • Research Area
    Inflammation/Immunology
  • Indication
    ——

Chemical Information

  • CAS Number
    193551-21-2
  • Formula Weight
    368.4048
  • Molecular Formula
    C20H21FN4O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    O[C@H]1CC[C@H](N2C(C3=NC(OC)=NC=C3)=C(C4=CC=C(F)C=C4)N=C2)CC1
  • Chemical Name
    Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Underwood DC, et al. J Pharmacol Exp Ther. 2000 Apr;293(1):281-8. 2. Underwood DC, et al. Am J Physiol Lung Cell Mol Physiol. 2000 Nov;279(5):L895-902. 3. Barone FC, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):312-21. 4. Legos JJ, et al. Brain Res. 2001 Feb 16;892(1):70-7.
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