TNIK-IN-5

Research use only, not for human use.

TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.

TNIK-IN-5 is an inhibitor of TNIK and can be used in studies about the treatment of anti-tumor and anti-inflammatory diseases.

TNIK-IN-5 (compound 8g) (1.25-5 μM; 48 hours) significantly inhibits the cell proliferation of HCT116 in a dose-dependent manner.TNIK-IN-5 (1 μM; 24, 48 hours) strongly prevents HCT116 cells migration.TNIK-IN-5 (10-40 μM; 48 hours) concentration-dependently inhibits the protein levels of β-catenin and TCF-4 in the nucleus, and significantly decreases the expression of Wnt target gene products, including Axin2 and c-Myc.Cell Proliferation Assay Cell Line:HCT116?cells Concentration:1.25 μM, 2.5 μM, 5 μMIncubation Time:48 hours Result:Significantly inhibited the cell proliferation in a dose-dependent manner.

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Wnt/Notch/Hedgehog

Wnt/beta/catenin

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2754265-66-0

371.39

C22H17N3O3

>98% (HPLC)

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O=C1OC=2C=C(C=CC2N1CC=3C=CC=C(OC)C3)C4=CN=C5NC=CC5=C4

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(-20℃)

With Ice Pack

≥ 2 years