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TRPM4 inhibitor 8

CAS No. 1353979-43-7

TRPM4 inhibitor 8( —— )

Catalog No. M28894 CAS No. 1353979-43-7

TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 41 In Stock
5MG 37 In Stock
10MG 56 In Stock
25MG 92 In Stock
50MG 176 In Stock
100MG 276 In Stock
200MG 416 In Stock
500MG 682 In Stock
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Biological Information

  • Product Name
    TRPM4 inhibitor 8
  • Note
    Research use only, not for human use.
  • Brief Description
    TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
  • Description
    TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
  • In Vitro
    NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    Endothelin A receptor|Endothelin B receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1353979-43-7
  • Formula Weight
    257.175
  • Molecular Formula
    C11H17BrN2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (388.85 mM)
  • SMILES
    CCN(CCN)Cc1cccc(Br)c1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
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