Cart
sales@molnova.com
TRPM4 inhibitor 8
CAS No. 1353979-43-7
TRPM4 inhibitor 8( —— )
Catalog No. M28894 CAS No. 1353979-43-7
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
|
| 5MG | 37 | In Stock |
|
| 10MG | 56 | In Stock |
|
| 25MG | 92 | In Stock |
|
| 50MG | 176 | In Stock |
|
| 100MG | 276 | In Stock |
|
| 200MG | 416 | In Stock |
|
| 500MG | 682 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRPM4 inhibitor 8
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
-
DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
-
In VitroNMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorEndothelin A receptor|Endothelin B receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1353979-43-7
-
Formula Weight257.175
-
Molecular FormulaC11H17BrN2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (388.85 mM)
-
SMILESCCN(CCN)Cc1cccc(Br)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
molnova catalog
related products
-
RQ00203078
RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).
-
SB-705498
A potent, selective and orally bioavailable TRPV1 antagonist with pKi of 7.6 (inhibition of capsaicin-mediated activation of hTRPV1 receptor).
-
Methyl Kakuol
Methyl Kakuol is an agonist of TRPA1 with an EC50 of 0.27 μM and can be used in studies about acting as an active ingredient in MBST constituent Asiasari Radix.
