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TRPM4 inhibitor 8
CAS No. 1353979-43-7
TRPM4 inhibitor 8( —— )
Catalog No. M28894 CAS No. 1353979-43-7
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
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| 5MG | 37 | In Stock |
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| 10MG | 56 | In Stock |
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| 25MG | 92 | In Stock |
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| 50MG | 176 | In Stock |
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| 100MG | 276 | In Stock |
|
| 200MG | 416 | In Stock |
|
| 500MG | 682 | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameTRPM4 inhibitor 8
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NoteResearch use only, not for human use.
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Brief DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
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DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
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In VitroNMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorEndothelin A receptor|Endothelin B receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number1353979-43-7
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Formula Weight257.175
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Molecular FormulaC11H17BrN2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (388.85 mM)
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SMILESCCN(CCN)Cc1cccc(Br)c1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
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