Cart
sales@molnova.com
TRPM4 inhibitor 8
CAS No. 1353979-43-7
TRPM4 inhibitor 8( —— )
Catalog No. M28894 CAS No. 1353979-43-7
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 41 | In Stock |
|
| 5MG | 37 | In Stock |
|
| 10MG | 56 | In Stock |
|
| 25MG | 92 | In Stock |
|
| 50MG | 176 | In Stock |
|
| 100MG | 276 | In Stock |
|
| 200MG | 416 | In Stock |
|
| 500MG | 682 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTRPM4 inhibitor 8
-
NoteResearch use only, not for human use.
-
Brief DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
-
DescriptionTRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
-
In VitroNMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.
-
In Vivo——
-
Synonyms——
-
PathwayMembrane Transporter/Ion Channel
-
TargetTRP/TRPV Channel
-
RecptorEndothelin A receptor|Endothelin B receptor
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1353979-43-7
-
Formula Weight257.175
-
Molecular FormulaC11H17BrN2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (388.85 mM)
-
SMILESCCN(CCN)Cc1cccc(Br)c1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6.
molnova catalog
related products
-
AM404
AM404 is an endocannabinoid reuptake inhibitor, a TRPV(1) activator, a paracetamol metabolite, with neuroprotective and anticancer activity that blocks anandamide transport.
-
AMG-333
AMG-333 (AMG333, AMG 333) is a novel potent, highly selective TRPM8 antagonist with IC50 of 13 nM and 20 nM for hTRPM8 and rTRPM8, respectively.
-
GFB-8438
GFB-8438 is a potent and subtype selective inhibitor of TRPC5(IC50s of 0.18 and 0.29 μM of hTRPC5 and hTRPC4, respectively).
