RQ00203078( RQ-00203078 | RQ 00203078 | RQ00203078 )

Catalog No. M11029 CAS No. 1254205-52-1

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

RQ00203078
Note

Research use only, not for human use.
Brief Description

RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).
Description

RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
In Vitro

——
In Vivo

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Synonyms

RQ-00203078 | RQ 00203078 | RQ00203078
Pathway

Membrane Transporter/Ion Channel
Target

TRP/TRPV Channel
Recptor

TRPM8
Research Area

Cancer
Indication

——

CAS Number

1254205-52-1
Formula Weight

554.85
Molecular Formula

C21H13ClF6N2O5S
Purity

>98% (HPLC)
Solubility

DMSO: 100 mM
SMILES

O=C(O)C1=CC=C(S(=O)(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC3=CC=C(OC(F)(F)F)C=C3)=O)C=C1
Chemical Name

4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

1. Chaussade C, et al. Biochem J, 2007, 404(3), 449-58.

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