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RQ00203078

CAS No. 1254205-52-1

RQ00203078( RQ-00203078 | RQ 00203078 | RQ00203078 )

Catalog No. M11029 CAS No. 1254205-52-1

RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 50 In Stock
5MG 41 In Stock
10MG 68 In Stock
25MG 120 In Stock
50MG 183 In Stock
100MG 343 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    RQ00203078
  • Note
    Research use only, not for human use.
  • Brief Description
    RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively).
  • Description
    RQ-00203078 is a highly selective, potent and orally available TRPM8 antagonist (IC50 values are 5.3 and 8.3 nM for rat and human channels respectively), exhibits >350-fold selectivity for TRPM8 over TRPV4, TRPV1 and TRPA1.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    RQ-00203078 | RQ 00203078 | RQ00203078
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRPM8
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1254205-52-1
  • Formula Weight
    554.85
  • Molecular Formula
    C21H13ClF6N2O5S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: 100 mM
  • SMILES
    O=C(O)C1=CC=C(S(=O)(N(C2=NC=C(C(F)(F)F)C=C2Cl)CC3=CC=C(OC(F)(F)F)C=C3)=O)C=C1
  • Chemical Name
    4-(N-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-(trifluoromethoxy)benzyl)sulfamoyl)benzoic acid

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chaussade C, et al. Biochem J, 2007, 404(3), 449-58.
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