AZD-9574

Research use only, not for human use.

AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.

AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.(In Vitro):AZD-9574 inhibits PARP1 with IC50s range between 0.3-2 nM in all tested cell lines which is >8000-fold selectivity compared to PARP2, PARP3, PARP5a and PARP6.(In Vivo):In an intracranial xenograft mice model of breast cancer brain metastases, AZD-9574 (3 mg/kg) shows sustained tumour growth suppression and results in a significantly extended survival of mice.

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Cell Cycle/DNA Damage

PARP

Antifection

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2756333-39-6

428.44

C21H22F2N6O2

>98% (HPLC)

In Vitro:?DMSO : 22.22 mg/mL (51.86 mM)

O=C(NC)C1=NC(F)=C(C=C1)N2CCN(CC=3C=CC=4N=C(C(=O)NC4C3F)C)CC2

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(-20℃)

With Ice Pack

≥ 2 years