SRI-011381( SRI-011381 | SRI 011381 | SRI011381 )

Catalog No. M17348 CAS No. 1629138-41-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

SRI-011381
Note

Research use only, not for human use.
Brief Description

SRI-011381, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.
Description

SRI-011381 is an agonist of the TGF-beta signaling pathway for treatment of Alzheimer's disease.
In Vitro

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In Vivo

Animal Model:YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)Dosage:30 mg/kg .Administration:Intraperitoneally injection; every 2 d; for 22 days Result:Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice.
Synonyms

SRI-011381 | SRI 011381 | SRI011381
Pathway

Cell Cycle/DNA Damage
Target

PARP
Recptor

Others
Research Area

——
Indication

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CAS Number

1629138-41-5
Formula Weight

329.48
Molecular Formula

C20H31N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (151.75 mM)
SMILES

O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[C@H]4CC[C@@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
Chemical Name

N'-Cyclohexyl-N-(phenylmethyl)-N-(4-piperidinylmethyl)-urea