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OATD-01
CAS No. 2088453-21-6
OATD-01( —— )
Catalog No. M28787 CAS No. 2088453-21-6
OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 126 | In Stock |
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| 2MG | 70 | In Stock |
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| 5MG | 116 | In Stock |
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| 10MG | 188 | In Stock |
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| 25MG | 353 | In Stock |
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| 50MG | 517 | In Stock |
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| 100MG | 728 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameOATD-01
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NoteResearch use only, not for human use.
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Brief DescriptionOATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).
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DescriptionOATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase).(In Vitro):The Ki values for hCHIT1,mCHIT1, hAMCase and mAMCase are 17.3 nM, 26.05 nM, 4.8 nM and 5.7 nM, respectively. These Ki values reveals good correlation with earlier established IC50 data, which are 23 nM, 28 nM, 9 nM and 7.8 nM, respectively. OATD-01 shows excellect PK profile in multiple species and is selectivity against a panel of other off-targets.(In Vivo):OATD-01 given orally once daily in a range of doses between 30 and 100 mg/kg showed significant antifibrotic efficacy in an animal model of bleomycin-induced pulmonary fibrosis.
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In Vitro——
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In VivoAnimal Model:Female BALB/c mice Dosage:30 mg/kg, 100 mg/kg Administration:Oral gavage; 30 mg/kg, 100 mg/kg; once daily; 21 days Result:Reduced the degree of lung fibrosis in vivo.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorPDE3A
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Research Area——
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Indication——
Chemical Information
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CAS Number2088453-21-6
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Formula Weight390.91
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Molecular FormulaC19H27ClN6O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (255.81 mM)
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SMILESC[C@@H](C1)OC[C@H](Cc(cc2)ccc2Cl)N1C(CC1)CCN1c1nc(N)n[nH]1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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BAY 2416964
BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1 (example 192, IC50: 341 nM). It has the potential for cancer treatment.BAY 2416964 induces AHR-regulated gene CYP1A1 expression in human monocytic U937 cells (IC50: 4.3 nM).
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Esculentoside A
Esculentoside A can suppress inflammatory responses in LPS-induced ALI through inhibition of the NF-κB and mitogen-activated protein kinase signaling pathways.
