CLEFMA

Research use only, not for human use.

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.

CLEFMA has anti-proliferative activity. CLEFMA inhibits tumor growth associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects.(In Vitro):CLEFMA induces autophagic death in H441 cells. CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively. CLEFMA induces apoptosis and reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.(In Vivo):Daily intraperitoneal injection of 0.2-0.4 mg/kg CLEFMA for 4 weeks, CLEFMA inhibits tumor growth and FDG uptake in tumor tissue in a xenograft mouse model . In addition, CLEFMA downregulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2, and survivin, and induces the cleavage and expression of the pro-apoptotic protein BID .

CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity.CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively.CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells.CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells.CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner.Cell Proliferation Assay Cell Line:PANC-1, MiaPaCa-2, PC-3 and H441 cells Concentration:1, 10, 25, 100 μM Incubation Time:24, 48, 72 h Result:Inhibits cells proliferation in a dose-dependent manner.

CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model.CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue. Animal Model:Male athymic nu/nu mice (4 weeks old) are injected H441 cells Dosage:0.2, 0.4 mg/kg Administration: I.p. daily for 4 weeks Result:Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.

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Apoptosis

NF-κB

Antibiotic

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1246964-32-8

442.29

C23H17Cl2NO4

>98% (HPLC)

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OC(/C=C\C(N(C/C(/C1=O)=C\c(cccc2)c2Cl)C/C1=C\c(cccc1)c1Cl)=O)=O

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(-20℃)

With Ice Pack

≥ 2 years