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Home - Products - MAPK/ERK Signaling - p38 MAPK - HPK1-IN-7

HPK1-IN-7

CAS No. 2320462-65-3

HPK1-IN-7( —— )

Catalog No. M28709 CAS No. 2320462-65-3

HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 167 In Stock
5MG 167 In Stock
10MG 276 In Stock
25MG 449 In Stock
50MG 603 In Stock
100MG 830 In Stock
200MG 1097 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    HPK1-IN-7
  • Note
    Research use only, not for human use.
  • Brief Description
    HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
  • Description
    HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM).
  • In Vitro
    ——
  • In Vivo
    Animal Model:Mice (MC38 syngeneic tumor model)Dosage:100 mg/kg Administration:Oral; twice daily for 28 days Result:Enhanced the efficacy of anti-PD1 treatment, garnering a 100% cure rate vs a 20% cure rate with anti-PD1 alone.
  • Synonyms
    ——
  • Pathway
    MAPK/ERK Signaling
  • Target
    p38 MAPK
  • Recptor
    Endothelin-1 receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2320462-65-3
  • Formula Weight
    458.478
  • Molecular Formula
    C24H22N6O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (272.65 mM)
  • SMILES
    CC1(C)OC(=O)c2ccc(Nc3ncc(-c4nnco4)c(N[C@H](CO)c4ccccc4)n3)cc12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Kohno M, et al. Atrial and brain natriuretic peptides inhibit the endothelin-1 secretory response to angiotensin II in porcine aorta. Circ Res. 1992 Feb;70(2):241-7
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