Cart
sales@molnova.com
CYM50358
CAS No. 1314212-39-9
CYM50358( —— )
Catalog No. M28705 CAS No. 1314212-39-9
N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 126 | In Stock |
|
| 5MG | 116 | In Stock |
|
| 10MG | 188 | In Stock |
|
| 25MG | 432 | In Stock |
|
| 50MG | 625 | In Stock |
|
| 100MG | 889 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameCYM50358
-
NoteResearch use only, not for human use.
-
Brief DescriptionN-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.
-
DescriptionN-(4-(aminomethyl)-2,6-dimethylphenyl)-5 is a potent, selective antagonist of the sphingosine-1-phosphate receptor 4 (S1P4). CYM50358 inhibits S1P4 with an IC50 of 25 nM.(In Vitro):N-(4-(aminomethyl)-2,6-dimethylphenyl)-5 shows less potent inhibition of S1PR1(IC50=6.4μM).N-(4-(aminomethyl)-2,6-dimethylphenyl)-5(10μM)has no effect on the collagen-induced HSP27 phosphorylation,markedly reverses the suppressive effect of S1P on the collagen-induced phospphorylation of HSP27.
-
In Vitro——
-
In Vivo——
-
Synonyms——
-
PathwayOthers
-
TargetOther Targets
-
RecptorPLD1
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1314212-39-9
-
Formula Weight389.28
-
Molecular FormulaC20H18Cl2N2O2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (321.11 mM)
-
SMILESCc1cc(CN)cc(C)c1NC(=O)c1ccc(o1)-c1cc(Cl)ccc1Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Lewis JA, et al. Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg Med Chem Lett. 2009;19(7):1916-1920.
molnova catalog
related products
-
NE 10790
NE 10790 is a phosphonocarboxylate analogue of the potent bisphosphonate risedronate and is a weak anti-resorptive agent.
-
Isorhoifolin
Isorhoifolin and vicenin II are main compounds of ethyl acetate fraction (EAcF) obtained from Erythrina velutina leaves, EAcF increases the cardiac contractile force by increasing the l-type calcium current and activating the adrenergic receptor pathway.
-
CEF8, Influenza Viru...
CEF8, Influenza Virus NP 383-391 is an influenza A virus nucleoprotein containing residues 383 to 391.
