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L-Glutamic acid monosodium salt

CAS No. 142-47-2

L-Glutamic acid monosodium salt( Monosodium glutamate | Sodium glutamate | MSG )

Catalog No. M18010 CAS No. 142-47-2

L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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100MG 43 In Stock
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Biological Information

  • Product Name
    L-Glutamic acid monosodium salt
  • Note
    Research use only, not for human use.
  • Brief Description
    L-Glutamic acid monosodium salt (Monosodium glutamate) is an activator of mGlu1 receptor.
  • Description
    Monosodium glutamate is one of the FLAVORING AGENTS used to impart a meat-like flavor. Medically it has been used to reduce blood ammonia levels in ammoniacal azotemia, therapy of hepatic coma, in psychosis, and INTELLECTUAL DISABILITY.
  • In Vitro
    Cell Viability Assay Cell Line: SH-SY5Y, IMR-32, SK-N-BE(2)Concentration:2, 5, 10, 20 mM Incubation Time: 24 and 48 h Result:Reduced cell viability in a dose-dependent manner.
  • In Vivo
    Animal Model:Crv4 mice model Dosage:3g/kg Administration:s.c., single dose Result:Reduced the number of Brn-3a+ RGCs by >70%.In the absence of mGlu1 receptor, MSG-induced retinal damage is diminished.Animal Model:CPF-induced rat model Dosage:750 mg/kg Administration:i.p.Result:Reduced CPF-induced oxidative stress by increasing the level of GSH and activity of GSH-related enzymes.
  • Synonyms
    Monosodium glutamate | Sodium glutamate | MSG
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    mGluR1
  • Research Area
    Others-Field
  • Indication
    ——

Chemical Information

  • CAS Number
    142-47-2
  • Formula Weight
    169.11
  • Molecular Formula
    C5H8NO4·Na
  • Purity
    >98% (HPLC)
  • Solubility
    H2O : ≥ 100 mg/mL; 591.33 mM
  • SMILES
    C(CC(=O)O)[C@@H](C(=O)[O-])N.[Na+]
  • Chemical Name
    sodium (S)-2-amino-4-carboxybutanoate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liberatore F, et al. Permissive role for mglu1 metabotropic glutamate receptors in excitotoxic retinal degeneration. Neuroscience. 2017 Sep 14. pii: S0306-4522(17)30640-1.
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