Thalidomide-NH-PEG1-NH2 hydrochloride( 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl )

Catalog No. M28662 CAS No. 2154342-56-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Thalidomide-NH-PEG1-NH2 hydrochloride
Note

Research use only, not for human use.
Brief Description

Thalidomide-NH-PEG1-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker.
Description

Thalidomide-NH-PEG1-NH2 hydrochloride is a synthetic E3 ligase ligand-linker conjugate that incorporates the Thalidomide-based cereblon ligand and a linker.
In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
In Vivo

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Synonyms

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Pathway

Others
Target

Other Targets
Recptor

TGFβRI
Research Area

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Indication

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1.Flavia Mercer Pernasetti, et al. Combinations of tgfb inhibitors and cdk inhibitors for the treatment of breast cancer. Patent WO2020058820A1.

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