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IMP-1088
CAS No. 2059148-82-0
IMP-1088( —— )
Catalog No. M28622 CAS No. 2059148-82-0
IMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 311 | In Stock |
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| 2MG | 188 | In Stock |
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| 5MG | 282 | In Stock |
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| 10MG | 468 | In Stock |
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| 25MG | 833 | In Stock |
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| 50MG | 1097 | In Stock |
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| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIMP-1088
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NoteResearch use only, not for human use.
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Brief DescriptionIMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.
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DescriptionIMP-1088 is a potent inhibitor of human N-myristoyltransferases NMT1 and NMT2 dual.(In Vitro):IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection.IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h.
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In VitroIMP-1088 (1-1000 nM) prevents virus-induced cytopathic effect (CPE) in a dose-dependent manner with an IC50 of 17 nM. IMP-1088 (125 nM) complete suppresses of new infectious virus with an IC50 of 5.8 nM. IMP-1088 (1-1000 nM) blocks production of infectious virus and inhibits single cycle replication in primary human bronchial epithelial cells (hBEC) infected with rhinovirus RV-A1 (MOI 5) for 7 h. IMP-1088 significantly inhibits production of infectious virus even when added up to 3 hours post-infection. IMP-1088 (50 nM) significantly less enriches multiple N-myristoylated proteins in enriched samples. IMP-1088 (500 nM) inhibits production of infectious rhinovirus particles by blocking virus assembly in HeLa cells infected with rhinovirus RV-A16 (MOI 20) for 6 h. IMP-1088 (0.24 nM-1 μM; for 24 hours +24 hours washout) has no long-term effect on cell viability and NMT activity fully recovers by 24 h. IMP-1088 potently blocks a key step in viral capsid assembly by inhibition of co-translational myristoylation of a specific virus-encoded protein (VP0). IMP-1088 blocks neither production of viral RNA, nor translation of rhinovirus polyprotein.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorD4 Receptor
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Research Area——
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Indication——
Chemical Information
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CAS Number2059148-82-0
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Formula Weight453.53
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Molecular FormulaC25H29F2N5O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (220.49 mM)
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SMILESCc1c(CCOc(c(-c(cc2)cc3c2n(C)nc3CN(C)C)ccc2F)c2F)c(C)nn1C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Belliotti TR, et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502.
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