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MMP-12 Inhibitor
CAS No. 1258003-93-8
MMP-12 Inhibitor( MMP408 | MMP12 )
Catalog No. M28533 CAS No. 1258003-93-8
MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 426 | In Stock |
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| 10MG | 641 | In Stock |
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| 25MG | 1096 | In Stock |
|
| 50MG | 1608 | In Stock |
|
| 100MG | 2413 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
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Biological Information
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Product NameMMP-12 Inhibitor
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NoteResearch use only, not for human use.
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Brief DescriptionMMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.
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DescriptionMMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12.(In Vitro):MMP-12 Inhibitor shows weaker activity against human MMP-3, MMP-13, and MMP-14 with IC50s of 351, 120, and 1100 nM.(In Vivo):In mice, MMP-12 Inhibitor (5 mg/kg, p.o.) effectively alleviates rhMMP-12-induced pulmonary inflammatory response by more than 50%.
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In Vitro——
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In Vivo——
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SynonymsMMP408 | MMP12
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PathwayMetabolic Enzyme/Protease
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TargetMMP
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1258003-93-8
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Formula Weight420.44
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Molecular FormulaC19H20N2O7S
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C(OC)=O)C=1C=C2C=3C(OC2=CC1)=CC(S(N[C@H](C(C)C)C(O)=O)(=O)=O)=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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Histatin 5 (TFA)(115...
Histatin 5 TFA inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.Histatin 5 is a member of a family of low-molecular-weight salivary proteins secreted by parotid, submandibular, and sublingual glands. Using biotinylated gelatin as a substrate, Histatin 5 is found to inhibit the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.
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Epitheaflagallin 3-O...
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts.
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MMP2-IN-3
MMP2-IN-3 is a potent inhibitor of matrix metalloproteinases (MMP-2) (IC50: 31 μM). MMP2-IN-3 inhibits MMP-9 and MMP-8 with IC50s of 26.6 and 32 μM, respectively.
