ML-SA5( —— )

Catalog No. M28506 CAS No. 2418670-70-7

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Datasheet

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Product Name

ML-SA5
Note

Research use only, not for human use.
Brief Description

ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.
Description

ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes.(In Vitro):Activating MCOLN1 with ML-SA5 triggers cell death of a number of cancer cells by evoking autophagic arrest and subsequent apoptotic response and cell cycle arrest, with little or no effect observed on normal cells.(In Vivo):ML-SA5 in Patu 8988 t xenograft mice profoundly suppresses tumor growth and improves survival.
In Vitro

ML-SA5(1-100 μM, 24 h) has some cell-targeting specificity and induces substantial cell death in M12 and MeWo cells, but fully preserves normal melanocytes. It also causes a loss of mitochondrial membrane potential in M12 cells.
In Vivo

ML-SA5 (i.p., 2-5 mg/kg, daily, 2 weeks) reduces muscle necrosis in MDX mice by more than 70% and reduces central nucleated fibers, suggesting that ML-SA5 can improve muscle atrophy in mdx mice in vivo by promoting myosin repair, but has no effect in ML1 knockout mice. Moreover, ML-SA5 reduces skeletal and cardiac muscle damage in mdx mice through ML1 upregulation.
Synonyms

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Pathway

Autophagy
Target

Autophagy
Recptor

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Research Area

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Indication

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