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Oxyphenisatin acetate

CAS No. 115-33-3

Oxyphenisatin acetate( —— )

Catalog No. M20707 CAS No. 115-33-3

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
1 mL x 10 mM in DMSO 29 In Stock
10MG 29 In Stock
25MG 36 In Stock
50MG 43 In Stock
100MG 60 In Stock
200MG 86 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock
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Biological Information

  • Product Name
    Oxyphenisatin acetate
  • Note
    Research use only, not for human use.
  • Brief Description
    Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.
  • Description
    Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.
  • In Vitro
    Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.
  • In Vivo
    Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    115-33-3
  • Formula Weight
    401.41
  • Molecular Formula
    C24H19NO5
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:150 mg/mL (373.68 mM)
  • SMILES
    CC(=O)Oc1ccc(cc1)C1(C(=O)Nc2ccccc12)c1ccc(OC(C)=O)cc1
  • Chemical Name
    2-Indolinone 33-bis(p-hydroxyphenyl)- diacetate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Morrison B L Mullendore M E Stockwin L H et al. Oxyphenisatin acetate (NSC 59687) triggers a cell starvation response leading to autophagy mitochondrial dysfunction and autocrine TNFα-mediated apoptosis[J]. Cancer Medicine 2013:n/a-n/a.
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