Oxyphenisatin acetate

Research use only, not for human use.

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7 T47D HS578T and MDA-MB-468.

Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468. In the estrogen receptor (ER) positive MCF7 and T47D cells, oxyphenisatin acetate induces TNFα expression and TNFR1 degradation, indicating autocrine receptor-mediated apoptosis in these lines. Ten micromoles per liter Oxyphenisatin acetate treatment results in autophagy and mitochondrial dysfunction.

Oxyphenisatin acetate (300 mg/kg, i.p.) delivers intraperitoneally inhibited tumor growth, accompanied by phosphorylation of eIF2α and degradation of TNFR1 in an MCF7 xenograft model.

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Autophagy

Autophagy

Autophagy

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115-33-3

401.41

C24H19NO5

>98% (HPLC)

DMSO:150 mg/mL (373.68 mM)

CC(=O)Oc1ccc(cc1)C1(C(=O)Nc2ccccc12)c1ccc(OC(C)=O)cc1

2-Indolinone 33-bis(p-hydroxyphenyl)- diacetate

(-20℃)

With Ice Pack

≥ 2 years