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Sivopixant
CAS No. 2414285-40-6
Sivopixant( S-600918 )
Catalog No. M28274 CAS No. 2414285-40-6
Sivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 238 | In Stock |
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| 2MG | 120 | In Stock |
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| 5MG | 187 | In Stock |
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| 10MG | 283 | In Stock |
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| 25MG | 452 | In Stock |
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| 50MG | 631 | In Stock |
|
| 100MG | 848 | In Stock |
|
| 200MG | 1135 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSivopixant
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NoteResearch use only, not for human use.
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Brief DescriptionSivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .
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DescriptionSivopixant (S-600918) is a potent and selective P2X3 receptor antagonist (P2X3 IC 50 =4.2 nM; P2X2/3 IC 50 =1100 nM). Sivopixant shows strong analgesic effect .(In Vivo):Sivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED 50 =0.4 mg/kg) .
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In Vitro——
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In VivoSivopixant (S-600918) (i.v.;1 mg/kg) shows a longer half-life (T1/2= 10.1 hours) and a strong analgesic effect in the rat Seltzer model of allodynia (ED50=0.4 mg/kg).
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SynonymsS-600918
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PathwayMembrane Transporter/Ion Channel
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TargetP2X Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number2414285-40-6
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Formula Weight507.93
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Molecular FormulaC25H22ClN5O5
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Purity>98% (HPLC)
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Solubility——
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SMILESC[C@@H](CN(C(N/C(/N1Cc(cc2)ccc2Cl)=N\c(cc2)ccc2Oc2ncccc2)=O)C1=O)C(O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Takahashi T, et al. Absence of cholic acid 7 alpha-dehydroxylase activity in the strains of Lactobacillus and Bifidobacterium. J Dairy Sci. 1994 Nov;77(11):3275-86.
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