Metallo β-lactamase ligand 1

Research use only, not for human use.

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.

Metallo β-lactamase ligand 1 is an inhibitor of class B β-lactamase exhibiting antibacterial activities.(In Vitro):The toxicity of Metallo β-lactamase ligand 1 is extremely low in HeLa cells.(In Vivo):Administration of Metallo β-lactamase ligand 1 significantly improves the survival rate in mice infected with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced).

One effective measure against β-lactam antibacterial resistant bacteria is to use an inhibitor of β-lactamase, the enzyme responsible for its resistance mechanism, together with an appropriate β-lactam antibacterial agent. The toxicity of Metallo-beta-lactamase ligand 1 (Compound A) is extremely low in HeLa cells.

After infecting mice with an experimental strain (E. coli strain into which a plasmid encoding class B β-lactamase (IMP-1) is introduced), Metallo-beta-lactamase ligand 1 (compound A; 100 mg/kg; intraperitoneal injection) is administered, and life and death are observed. Administration of Metallo-beta-lactamase ligand 1 (compound A) significantly improves the survival rate.

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GPCR/G Protein

Antibacterial

IL-1β| IL-10

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1087784-71-1

219.21

C7H9NO5S

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (1140.41 mM)

Cc1oc(C)c(c1C(O)=O)S(N)(=O)=O

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(-20℃)

With Ice Pack

≥ 2 years