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Propargylcholine
CAS No. 111755-76-1
Propargylcholine( Propargylcholine (bromide) )
Catalog No. M28160 CAS No. 111755-76-1
Propargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 35 | In Stock |
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| 5MG | 29 | In Stock |
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| 10MG | 38 | In Stock |
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| 25MG | 85 | In Stock |
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| 50MG | 137 | In Stock |
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| 100MG | 231 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePropargylcholine
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NoteResearch use only, not for human use.
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Brief DescriptionPropargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
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DescriptionPropargylcholine is an alkyne-modified choline analog and inhibits choline catabolism at the level of Dgc enzyme-catalyzed dimethylglycine demethylation in Pseudomonas aeruginosa.
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In VitroPropargylcholine bromide (10, 50 μM; 24 h) incorporates into NIH 3T3 cells and shows strong staining in a concentration-dependent manner (fixed and stained with Alexa568-azide). Immunofluorescence Cell Line:NIH 3T3 cells Concentration:10, 50 μM Incubation Time:24 h Result:Showed strong staining proportional in intensity to the concentration of added Propargylcholine bromide.
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In VivoPropargylcholine bromide (P-Cho; 3.5-4.0 mg/kg; i.p; single daily for 6 days) effectivelyincorporates into newly synthesized myelin within 1 week of dosing and sustained presence beyond 6 weeks in rhesus monkey.
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SynonymsPropargylcholine (bromide)
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PathwayGPCR/G Protein
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TargetAntibacterial
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RecptorBacterial|PGE2|COX-1|E. coli
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Research Area——
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Indication——
Chemical Information
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CAS Number111755-76-1
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Formula Weight208.099
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Molecular FormulaC7H14BrNO
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Purity>98% (HPLC)
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SolubilityIn Vitro:?H2O : 125 mg/mL (600.67 mM)
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SMILES[Br-].C[N+](C)(CCO)CC#C
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Zhou Yin,et al. DNA replication is the target for the antibacterial effects of nonsteroidal anti-inflammatory drugs. Chem Biol. 2014 Apr 24;21(4):481-487.
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