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Home - Products - Cell Cycle/DNA Damage - DNA/RNA Synthesis - 1-Hydroxyanthraquinone

1-Hydroxyanthraquinone

CAS No. 129-43-1

1-Hydroxyanthraquinone( —— )

Catalog No. M28115 CAS No. 129-43-1

1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    1-Hydroxyanthraquinone
  • Note
    Research use only, not for human use.
  • Brief Description
    1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.
  • Description
    1-Hydroxyanthraquinone is an anthraquinone that has been found in Morinda officinalis and has genotoxic and carcinogenic activities. 1-Hydroxyanthraquinone generates strong DNA repair response.(In Vitro):1-Hydroxyanthraquinone (5 and 500 μM) increases the percentage of isolated rat hepatocytes undergoing unscheduled DNA synthesis, indicating genotoxic activity.(In Vivo):Dietary administration of 1-Hydroxyanthraquinone (1%) induces formation of cecum and colon adenocarcinomas, as well as hepatocellular carcinomas, in rats.
  • In Vitro
    ——
  • In Vivo
    1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats. Animal Model:Thirty rats.Dosage:1% HA in diet.Administration:Diet.Result:Associated with decreased weight gain which was particularly marked towards the termination of experiment.One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment. A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.Seven animals of the group died spontaneously or were sacrificed upon becoming mori bund between 335 and 462 days.
  • Synonyms
    ——
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    DNA/RNA Synthesis
  • Recptor
    RORγt
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    129-43-1
  • Formula Weight
    224.215
  • Molecular Formula
    C14H8O3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 16.67 mg/mL (74.35 mM)
  • SMILES
    Oc1cccc2C(=O)c3ccccc3C(=O)c12
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.BAKONYI J, et, al. Compounds as modulators of ror gamma. US20150291607A1.
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