3-Deazauridine

Research use only, not for human use.

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase which is considered to be the primary mode of action of this nucleoside analog.(In Vitro):3-Deazauridine enhanced the in vitro antineoplastic action of 5-AZA-CdR on human leukemic cells by increasing its incorporation into DNA. Using an optimized dose-schedule we showed that this combination could cure some mice bearing L1210 leukemia, even in the presence of a subpopulation of drug-resistant (L1210/ARA-C) leukemic cells lacking DCK. 3-Deazauridine alone also cured some mice with L1210/ARA-C leukemia.

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Cell Cycle/DNA Damage

Nucleoside Antimetabolite/Analog

M2 mAChR

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23205-42-7

243.215

C10H13NO6

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (411.17 mM)

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1ccc(O)cc1=O

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(-20℃)

With Ice Pack

≥ 2 years