5-Azacytidine

Research use only, not for human use.

A chemical analog of Cytidine that inhibits DNA methyltransferase; induces mitochondrial apoptosis and autophagy.

A chemical analog of Cytidine that inhibits DNA methyltransferase; induces mitochondrial apoptosis and autophagy.Chemotherapeutic Agents Approved(In Vitro):Unmethylated CpG islands associated with a variety of genes become partially or fully methylated in tumors and can be reactivated by 5-Azacytidine. 5-Azacytidine acts as weak inducers of erythroid differentiation of Friend erythroleukemia cells in the same concentration range where they affect DNA methyltransferase activity. 5-Azacytidine inhibits L1210 cells with ID50 and ID90 values of 0.019 and circa 0.15 μg/mL, respectively.(In Vivo):TdR-3H incorporation is significantly inhibited when the animals are exposed to 5-Azacitidine (100 mg/kg, i.p.) for 2 hr or longer.

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Ladakamycin | 5-AzaC | Azacitidine

Cell Cycle/DNA Damage

Nucleoside Antimetabolite/Analog

DNAmethyltransferase(DNMT)

Cancer

Chemotherapeutic

320-67-2

244.2047

C8H12N4O5

>98% (HPLC)

DMSO: ≥ 31 mg/mL

O=C1N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C=NC(N)=N1

1,3,5-Triazin-2(1H)-one, 4-amino-1-β-D-ribofuranosyl-

(-20℃)

With Ice Pack

≥ 2 years