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BMS-986176
CAS No. 1815613-42-3
BMS-986176( LX-9211 | AAK1-IN-1 )
Catalog No. M28057 CAS No. 1815613-42-3
AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 377 | In Stock |
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| 5MG | 353 | In Stock |
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| 10MG | 528 | In Stock |
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| 25MG | 851 | In Stock |
|
| 50MG | 1135 | In Stock |
|
| 100MG | 1535 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | 5895 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-986176
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NoteResearch use only, not for human use.
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Brief DescriptionAAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
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DescriptionAAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).(In Vitro):AAK1-IN-1can be used for neurodegenerative disease studies. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases and modulates clatherin coated endocytosis. and receptor-mediated endocytosis.
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In VitroAdaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis.
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In Vivo——
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SynonymsLX-9211 | AAK1-IN-1
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PathwayOthers
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TargetOther Targets
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RecptorAntifungal
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Research Area——
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Indication——
Chemical Information
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CAS Number1815613-42-3
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Formula Weight385.4
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Molecular FormulaC19H23F4N3O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 220 mg/mL (570.84 mM)
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SMILESN/A
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
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CID-4785700
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Neuromedin S (human)
Neuromedin S (human) is a neuropeptide that contains 33 amino acids. Neuromedin S (human)has been identified in the brain as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1 and acts on the neuromedin U (NMU) receptor 2 (NMUR2) in the regulation of body weight homeostasis.
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Unifiram
Unifiram is a cognition-enhancer. Unifiram induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the rat hippocampal CA1 region (EC50= 27 nM) and increases acetylcholine (ACh) release in the rat cerebral cortex.
