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MTOB

CAS No. 51828-97-8

MTOB( 4-methylthio 2-oxobutyric acid | KMBA | MTOB salt | α-keto-γ-Methylthiobutyric acid )

Catalog No. M28000 CAS No. 51828-97-8

MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    MTOB
  • Note
    Research use only, not for human use.
  • Brief Description
    MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.
  • Description
    MTOB is a substrate for c-terminal binding protein (CtBP) that interferes with the carcinogenic activity of CtBP in cell culture and mice. It also actively regulates TCF-4 signaling, leading to cancer stem cell (CSC) growth and self-renewal.
  • In Vitro
    MTOB sodium (10 mM) causes significant derepression (P<0.05) of 40% of CtBP target genes (including FGF9, CTNNB1, CEBPB, et al.) in MCF-7 and 46% in MBA-MD-231; increases the pro-epithelial E-cadherin/Vimentin ratio while reducing the pro-mesenchymal CD44/CD24 ratio, with a more significant trend (P<0.05) in MCF-7.
  • In Vivo
    MTOB sodium (860 mg/kg; IP, at 1 h and 18 h after the first injury) effectively suppresses the increases duration of righting reflex, and significantly decreased neurological severity score (NSS) scores. Animal Model:C57BL/6 mice (traumatic brain injury)Dosage:860 mg/kg Administration:IP, at 1 h and 18 h after the first injuryResult:Effectively suppressed the increased duration of righting reflex, and significantly decreased NSS scores.
  • Synonyms
    4-methylthio 2-oxobutyric acid | KMBA | MTOB salt | α-keto-γ-Methylthiobutyric acid
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Antiviral
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    51828-97-8
  • Formula Weight
    170.16
  • Molecular Formula
    C5H7NaO3S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 125 mg/mL (734.60 mM)
  • SMILES
    [Na+].CSCCC(=O)C([O-])=O
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Byoung-Kwon Chun, et al. Preparation of nucleosides and methods for treatment of viral infections. WO2022047065A2
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