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RK-9123016
CAS No. 955900-27-3
RK-9123016( RK 9123016 | RK9123016 )
Catalog No. M27923 CAS No. 955900-27-3
RK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 46 | In Stock |
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| 5MG | 38 | In Stock |
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| 10MG | 61 | In Stock |
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| 25MG | 101 | In Stock |
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| 50MG | 144 | In Stock |
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| 100MG | Get Quote | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameRK-9123016
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NoteResearch use only, not for human use.
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Brief DescriptionRK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.
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DescriptionRK-9123016 is a SIRT2 inhibitor. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression.(In Vitro):RK-9123016 inhibited the enzymatic activity of SIRT2 with an IC50 value of 0.18 μM but not other human sirtuin members including SIRT1 and SIRT3 at 100 μM in vitro electrophoretic mobility shift assay. RK-9123016 inhibited the SIRT2 activity in MCF-7 cells by concentration dependent manner (0-30 μM).
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In Vitro——
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In Vivo——
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SynonymsRK 9123016 | RK9123016
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PathwayChromatin/Epigenetic
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TargetSirtuin
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RecptorFatty Acid Synthase (FASN)
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Research Area——
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Indication——
Chemical Information
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CAS Number955900-27-3
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Formula Weight374.42
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Molecular FormulaC16H18N6O3S
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Purity>98% (HPLC)
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Solubility——
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SMILESCOc1ccc(\C=N\NC(=S)NCC=C)cc1Cn1cc(cn1)[N+]([O-])=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Giorgia Zadra, et al. Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2019 Jan 8;116(2):631-640.
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