NS9283

Research use only, not for human use.

NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.

NS9283, a positive allosteric modulator selective for the α4β2 form, reduces ethanol consumption.(In Vitro):NS9283 increased the potency of varenicline to activate and desensitize α4β2 nAChRs in vitro without affecting other known targets of varenicline.(In Vivo):In male and female C57BL/6J mice, NS9283 (10 mg/kg) reduced ethanol intake in a two-bottle choice, intermittent drinking procedure without affecting saccharin intake, ethanol-induced incoordination or ethanol-induced loss of the righting reflex. Subthreshold doses of NS9283 (2.5 mg/kg) plus varenicline (0.1 mg/kg) synergistically reduced ethanol intake in both sexes. Finally, despite having no aversive valence of its own, NS9283 enhanced ethanol-conditioned place aversion.

——

——

NS 9283 | NS-9283

Cell Cycle/DNA Damage

AChR

lignostilbene-α,β-dioxygenase

——

——

913830-15-6

248.245

C14H8N4O

>98% (HPLC)

In Vitro:?DMSO : 16.67 mg/mL (67.15 mM)

N#Cc1cccc(c1)-c1nc(no1)-c1cccnc1

——

(-20℃)

With Ice Pack

≥ 2 years