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GSK3987
CAS No. 264206-85-1
GSK3987( —— )
Catalog No. M27880 CAS No. 264206-85-1
GSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 230 | Get Quote |
|
| 10MG | 372 | Get Quote |
|
| 25MG | 623 | Get Quote |
|
| 50MG | 887 | Get Quote |
|
| 100MG | 1197 | Get Quote |
|
| 500MG | 2394 | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGSK3987
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NoteResearch use only, not for human use.
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Brief DescriptionGSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.
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DescriptionGSK3987 is an LXR ligand. GSK3987 recruits the steroid receptor coactivator-1 to human LXRalpha and LXRbeta with EC50s of 40 nM.(In Vitro):In primary human macrophages, GSK3987 (30, 100, 300, 1000 nM) increased the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner. In human hepatoma (HepG2) cells, GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in a dose-dependent manner. GSK3987 showed activity with EC50s of 0.08 μM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively.
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In VitroRT-PCR Cell Line:HepG2 cells Concentration:6-1500 nM Incubation Time:Result:Increased the expression of SREBP-1c and induced triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner.
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In Vivo——
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorEP4
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Research Area——
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Indication——
Chemical Information
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CAS Number264206-85-1
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Formula Weight384.435
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Molecular FormulaC24H20N2O3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (260.13 mM)
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SMILESCOc1ccc(NC2=C(C(=O)N(Cc3ccccc3)C2=O)c2ccccc2)cc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yang JJ,?et al. Discovery and Characterization of 1H-1,2,3-Triazole Derivatives as Novel Prostanoid EP4 Receptor Antagonists for Cancer Immunotherapy. J Med Chem.?2020 Jan 23;63(2):569-590.
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