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AVN-101 hydrochloride?
CAS No. 1061354-48-0
AVN-101 hydrochloride?( AVN 101 | AVN101 )
Catalog No. M27852 CAS No. 1061354-48-0
AVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 93 | In Stock |
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| 5MG | 69 | In Stock |
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| 10MG | 117 | In Stock |
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| 25MG | 217 | In Stock |
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| 50MG | 346 | In Stock |
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| 100MG | 576 | In Stock |
|
| 200MG | 816 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAVN-101 hydrochloride?
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NoteResearch use only, not for human use.
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Brief DescriptionAVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors.
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DescriptionAVN-101 is a very potent 5-HT7 receptor antagonist (Ki = 153 pM). AVN-101 also exhibits a rather high affinity toward histamine H1 (Ki = 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki = 0.41-3.6 nM) receptors. AVN-101 shows a good oral bioavailability and facilitated brain-blood barrier permeability, low toxicity, and reasonable efficacy in animal models of CNS diseases.
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In Vitro——
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In Vivo——
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SynonymsAVN 101 | AVN101
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PathwayEndocrinology/Hormones
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Target5-HT Receptor
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Recptor——
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Research Area——
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Indication——
Chemical Information
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CAS Number1061354-48-0
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Formula Weight340.9
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Molecular FormulaC21H25ClN2
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Purity>98% (HPLC)
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Solubility——
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SMILESCl.CN1CCc2c(C1)c1cc(C)ccc1n2CCc1ccccc1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Nathaniel J Henning, et al. Deubiquitinase-targeting chimeras for targeted protein stabilization. Nat Chem Biol. 2022;18(4):412-421.
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