Venlafaxine hydrochloride( Wy 45030 )

Catalog No. M16910 CAS No. 99300-78-4

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Product Name

Venlafaxine hydrochloride
Note

Research use only, not for human use.
Brief Description

Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
Description

Venlafaxine hydrochloride is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.
In Vitro

——
In Vivo

Animal Model:Male Sprague-Dawley rats weighing 180-230 grams Dosage:10, 30, 100 mg/kg Administration:IP; one hour prior to p-chloramphetamine hydrochloride (p-CA; 10 mg/kg; i.p.)Result:Dose-dependently blocked the depletion of norepinephrine levels in rat hypothalamus induced by 6-OHDA (intracerebroventricularly; 50 μg/rat; one hour later), with ED50 values of 12 and 94 mg/kg i.p., respectively.
Synonyms

Wy 45030
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT
Research Area

Neurological Disease
Indication

——

CAS Number

99300-78-4
Formula Weight

313.86
Molecular Formula

C17H28CLNO2
Purity

>98% (HPLC)
Solubility

Ethanol: 55.5 mg/mL (176.83 mM); Water: 55.5 mg/mL (176.83 mM); DMSO: 55.5 mg/mL (176.83 mM)
SMILES

OC1(C(C2=CC=C(OC)C=C2)CN(C)C)CCCCC1.[H]Cl
Chemical Name

1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol hydrochloride

1.Ball SE, et al. Br J Clin Pharmacol, 1997, 43(6), 619-626.

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