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BZAD01

CAS No. 305339-41-7

BZAD01( BZAD-01 | BZAD 01 )

Catalog No. M27808 CAS No. 305339-41-7

BZAD01 is a selective NMDA NR1A/2B receptor antagonist.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    BZAD01
  • Note
    Research use only, not for human use.
  • Brief Description
    BZAD01 is a selective NMDA NR1A/2B receptor antagonist.
  • Description
    BZAD01 is a selective NMDA NR1A/2B receptor antagonist.(In Vivo):Parkinsonism was induced by microinjection of the toxin, 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle (MFB) of 40 Sprague-Dawley rats. Parkinsonism and the efficacy of drugs were assessed using a battery of behavioural tests including balance beam, apomorphine-induced rotation, body axis bias or "curling", head position bias and disengage sensorimotor latency test. The main effects were that BZAD01 co-administration prevented chronic levodopa-induced potentiation of apomorphine rotation. However levodopa-treated rats were slower than either controls or BZAD-01-treated rats in the locomotor test.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    BZAD-01 | BZAD 01
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    NMDAR
  • Recptor
    Guanylate cyclase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    305339-41-7
  • Formula Weight
    362.275
  • Molecular Formula
    C16H12F6N2O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?Methanol : 250 mg/mL (690.09 )
  • SMILES
    FC(F)(F)Oc1ccc(cc1)C(=N)NCc1ccccc1C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Barbara ALBRECHT-KüPPER, et al. Selective partial adenosine a1 receptor agonists in combination with soluble guanylyl cyclase (sgc) stimulators and/or activators. WO2018153899A1.
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