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PTP1B-IN-4
CAS No. 765317-72-4
PTP1B-IN-4( FRJ | NUN17724 | NUN-17724 | NUN 17724 | PTP1B inhibitor 4 | PTP1B-inhibitor-4 | )
Catalog No. M27767 CAS No. 765317-72-4
PTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 896 | Get Quote |
|
| 100MG | 1566 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NamePTP1B-IN-4
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NoteResearch use only, not for human use.
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Brief DescriptionPTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.
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DescriptionPTP1B-IN-4 is an allosteric PTP1B inhibitor with an IC50 of 8 μM. PTP1B-IN-4 can be used in studies about obesity and diabetes.(In Vitro):In CHO cells overexpressing human IR, PTP1B-IN-4 (250 μM) stimulates the phosphorylation of insulin receptors. PTP1B-IN-4 induces phosphorylation of IRS-1 and Akt which are proteins downstream of the insulin receptor.
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In VitroWestern Blot Analysis Cell Line:CHO cells Concentration:250 μM Incubation Time:1 hour Result:Stimulated insulin receptor phosphorylation.
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In Vivo——
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SynonymsFRJ | NUN17724 | NUN-17724 | NUN 17724 | PTP1B inhibitor 4 | PTP1B-inhibitor-4 |
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PathwayMetabolic Enzyme/Protease
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TargetPhosphatase
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RecptorFAK
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Research Area——
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Indication——
Chemical Information
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CAS Number765317-72-4
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Formula Weight741.45
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Molecular FormulaC26H19Br2N3O7S3
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (134.87 mM)
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SMILESCCc1oc2cc(ccc2c1C(=O)c1cc(Br)c(O)c(Br)c1)S(O)(=O)=O
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Yang XH, Xiang L, Li X, Zhao TT, Zhang H, Zhou WP, Wang XM, Gong HB, Zhu HL. Synthesis, biological evaluation, and molecular docking studies of 1,3,4-thiadiazol-2-amide derivatives as novel anticancer agents. Bioorg Med Chem. 2012 May 1;20(9):2789-95.
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